Oral Cavity Beta-Defensin Levels Are Regulated Differently during Radiotherapy in Head and Neck Cancer Patients

Background: Human beta-defensins (hBDs) are small cationic peptides of the epithelium with broad antimicrobial and immune response-regulatory activities. hBDs also related to oncogenesis, their secretion profiles affected by radiotherapy treatment. The present study aimed investigate oral cavity hBD 1-3 levels in head neck cancer patients its relation Methods: Sixteen (all a history smoking) were included this study. Periodontal parameters measured before radiotherapy, medical information was collected from registries. Oral rinses radiotherapy; on 1st, 3rd, 6th weeks 1st month following end radiotherapy. 1–3 using ELISA. Results: hBD-1 increased during at week 6 (p = 0.019). returned pretreatment after No significant change detected for hBD-2 or hBD-3 Conclusions: constant expression hBD-1, which is distinct infection inflammation-dependent hBD-3, may explain why peptide only one